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Indian Health Outcomes, Public Health and Economics Research Centre (IHOPE) Read More

Clinical Research

LVPEI has been successfully audited by United States - Food and Drug Administration Agency (US FDA) and European Medicine Agency (EMA) for performing clinical trials.

Clinical Trials conducted are registered under Clinical Trial Registry of India (CTRI) and Clinicaltrials.gov.

Institutional Ethics Committee (IEC) of LVPEI is registered with CDSCO and operates under NABH Accreditation Standards for the Clinical Trial Program.

Dr Sayan Basu,
Director of Research

Kallam Anji Reddy Campus
Network Administrator: T Charitha
Study Co-Ordinator’s: Vijaya, Ramya, Usha, Kavya, Sindupriya, Swetha, Divya, Pravallika
Study Optometrists: Swathi, Subba Rao
Contact Numbers (Clinical Research): 040-68102268/2269

Bhubaneswar Campus
Study Co-Ordinator’s: Asit, Mahima, Jyotibrahma, S Das
Study Optometrists: Kartik Jana
Contact Number: 06740 2653261

GMRV Campus
Study Coordinator: Sumitra
Contact Number: 8639732466

KVC Campus
Study Coordinator: Anusha
Contact Number: 7780309262

KAR CAMPUS- SPONSOR STUDIES
S.No Name of the project Principal Investigator Supported By Duration CTRI
1Long-term effects of semaglutide on diabetic retinopathy in subjects with type 2 diabetes (FOCUS) Dr.Padmaja KumariNovanordisk2020-2026http://ctri.nic.in
2A Prospective, Randomized, Multicenter, Masked, Pivotal Study to Assess the Safety and Effectiveness of BYNOCS DAT (Dichoptic Amblyopia Training) Game in Treating Children with Amblyopia Dr Sampada KulkarniBYNOCS2024-2026http://ctri.nic.in
3A Phase 1/2a Multi-Center, Dose-Escalation, Dose-Expansion Study to Evaluate the Safety and Efficacy of Eyecyte-RPETM when administered as a Single-dose Subretinal Injection in Subjects with Geographic Atrophy (GA) Secondary to Dry Age-related Macular Degeneration (d-AMD) Dr. Vivek DaveEye Stem2024-2026http://ctri.nic.in
4A Phase 3, Multicenter, Double-Masked, Randomized, Parallel Group Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects with Neovascular Age Related Macular DegenerationDr. Ritesh NarulaPFC Pharma2025-2026http://ctri.nic.in
5Evaluation of a novel Glaucoma Drainage Implant (GORE GDI) in Subjects with Primary Open – Angle GlaucomaDr. Sirisha SenthilW.L Gore & Associates, Inc2025-2026http://ctri.nic.in
6A phase IV, multicenter, open label, single arm study in patients with neovascular age -Related macular degeneration or diabetic Macular edema to evaluate safety and Effectiveness of the Faricimab intravitreal Injection in india (VITREAL study) Dr. Brijesh TakkarRoche Products2025-2026http://ctri.nic.in
7A randomized, double-blind, placebo-controlled study to assess the efficacy of' LN242l4 in relieving dry eye symptoms.Dr. Pragnya RaoLaila Nutra2025-2026http://ctri.nic.in
8Efficacy of spectacles with highly aspherical lens lets in children with high myopia.Dr. Pavan VerkicharlaEssilor Luxottica2025-2026http://ctri.nic.in
9Contact lenses utilizing S.T.O.P.® technology versus dual focus contact lenses for slowing down myopia progression in children: A three-year prospective, multi-center, controlled, masked, randomized, non-inferiority clinical trialDr. Pavan VerkicharlaNthalmic Pvt Ltd2025-2026http://ctri.nic.in
10A multi-centre, open-label, single-arm study to assess the safety and efficacy of collagen ophthalmic matrix for anterior lamellar keratoplasty.Dr. Bhupesh BaggaAcro Biomedical Co. Ltd2026http://ctri.nic.in
11Efficacy and safety assessment of Tl695 eyedrops suspension at 0.1%. versus Ciclosporin ophthalmic emulsion at 0.1% in patients with moderate to severe Vernal Keratoconjunctivitis (VKC).Dr. Sunita ChaurasiaThea2026-2027Ethics Ref. No. LEC-BHR-CT-10-2025-282

INVESTIGATOR INITITATED STUDIES
S.No Name of the project Principal Investigator CTRI/Ethics Committee
1Artificial Intelligence enabled referral pathways for early diagnosis of complications arising from diabetes: application to diabetic retinopathy. Dr. Padmaja Kumari Ranihttps://ctri.nic.in
2Safety And Efficacy of Collagenase application In Ocular Burns: A Prospective open- label Academic Randomized Controlled Trial. Dr. Sayan Basuhttps://ctri.nic.in
3Comparison the long-term safety and efficacy of PAUL ® Glaucoma Implant and Ahmed Implant in patients who are undergoing aqueous shunt implant surgery. Dr. Sirisha SenthilLEC-BHR-P-12-23-1148
4Comparative Efficacy of Natamycin Monotherapy vs. Natamycin with Posaconazole in Mild to Moderate Fungal Keratitis: A Randomized Controlled Trial Dr. Bhupesh Baggahttps://ctri.nic.in
5Efficacy of Topical Polymyxin B/Trimethoprim + Rifampin for the Treatment of KeratitisDr Amrita Mohantyhttps://ctri.nic.in
6Prospective study to evaluate the safety and efficacy of ICath device in Illuminated Microcatheter Assisted Transluminal Trabeculotomy (iMAT) Versus Combined Trabeculotomy and Trabeculectomy in patients with Primary Congenital Glaucoma.Dr. Sirisha Senthilhttps://ctri.nic.in/

MTC CAMPUS- SPONSOR STUDIES
S.No Name Of The Project Principal Investigator Supported By Duration CTRI
1A Prospective, Randomized, Multicenter, Masked, Pivotal Study to Assess the Safety and Effectiveness of BYNOCS DAT (Dichoptic Amblyopia Training) Game in Treating Children with Amblyopia.Dr.DebasmitaBYNOCS2024-2026http://ctri.nic.in
2A Multicenter, Double-Masked, Randomized, Vehicle-Controlled 12-Month (with a 12-month, Double-Masked Extension) Parallel Comparison of the Safety and Efficacy of 0.1% and 0.2% CBT-001 versus Vehicle, Dosed Twice-Daily, in Patients with Pterygium.Dr. Sujata DasCloud break Therapeutics2024-2026http://ctri.nic.in
3A Phase 3, Multicenter, Double-Masked, Randomized, Parallel Group Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects with Neovascular Age Related Macular DegenerationDr. Umesh Chandra BeheraPFC Pharma2024-2026http://ctri.nic.in
4A Prospective, Multicenter, Double-Blind, Active-Controlled, Parallel-Group, Phase III Study to Compare Efficacy, Safety and Immunogenicity of Sun’s Aflibercept with Reference Biologic in Patients with Neovascular Age-Related Macular degeneration (wet AMD) ICR/24/006Dr. Anup KelgaonkarSun pharma Pvt Ltd2025-2026http://ctri.nic.in
5Efficacy and safety assessment of Tl695 eyedrops suspension at 0.1%. versus Ciclosporin ophthalmic emulsion at 0.1% in patients with moderate to severe Vernal Keratoconjunctivitis (VKC).Dr. Srikant Kumar SahooThea2026-20272025-021-CT-16
6A multi-center, open-label, single-arm study to assess the safety and efficacy of collagen ophthalmic matrix for anterior lamellar keratoplasty.Dr. Sujata DasAcro Biomedical Co. Ltd2026http://ctri.nic.in

INVESTIGATOR INITITATED STUDIES - MTC CAMPUS
S.No Name of the project Principal Investigator CTRI/Ethics Committee
1Validating the Endophthalmitis Infectivity Measurement Algorithm (EIMA) Imaging tool Anup Kelgaonkar https://ctri.nic.in
2Effectiveness of systemic immunosuppressants for Dry eyes in Sjogren disease. Dr. Smruti Rekha Priyadarshini https://ctri.nic.in
3A Study Comparing Two Types of Laser Treatment in Patients with Chronic Central Serous Chorioretinopathy Dr. Umesh Chandra Behera https://ctri.nic.in

GMRV CAMPUS - SPONSOR STUDIES
S.No Name of the Project Principal Investigator Supported By Duration CTRI
1A Prospective, Randomized, Multicenter, Masked, Pivotal Study to Assess the Safety and Effectiveness of BYNOCS DAT (Dichoptic Amblyopia Training) Game in Treating Children with AmblyopiaDr.Virender SachdevaBYNOCS2024-2025http://ctri.nic.in

INVESTIGATOR INITITATED STUDIES - GMRV CAMPUS
S.No Name of the project Principal Investigator CTRI/Ethics Committee
1Identification of diagnostic biomarkers in vitreous/ aqueous fluid of ocular tuberculosis patients.(Ocular TB) Dr. Vishal Sanjay JadhavLEC-BHR-09-24-178
2Subclinical Gliptin-induced bullous pemphigoid in patients on oral gliptins Dr Shilpa TaruniLEC-BHR-02-24-172
3Clinical features, vision, visual function and retinal changes in eyes of Vogt Koyanagi Harada Syndrome after initial resolution of inflammation(VKH) Dr Vishal Sanjay JadhavLEC-BHR-09-24-179
4Functional assessments of pathogenic variants in the nuclear and mitochondrial genome contributing to the pathogenesis of hereditary optics neuropathiesDr Virender SachdevaLEC-BHR-07-22-131